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ALESSANDRA ANGELUCCI: STRUCTURE AND FUNCTION OF CORTICAL CIRCUITS

WHAT  
WE DO

Alessandra Angelucci Lab: We study the anatomical organization and function of neural circuits in the visual cortex to understand how these circuits compute the cortical computations that generate perception. We use a multidisciplinary approach encompassing neuroanatomical methods, array electrophysiology, brain imaging, optogenetics and computational modeling to understand how specific circuit wiring leads to cortical neuron responses.

NIH GRANT

Alessandra Angelucci receives NIH/NEI R01 grant to study the connectivity and function of inter-areal feedback connections in the visual cortex.

NIH GRANT

Alessandra Angelucci receives NIH/NEI R01 grant to study the connectivity and function of different classes of inhibitory neurons in the visual cortex

NEWS

Jenny was among the most influential neuroanatomists of the 20th century, who dedicated her career to understanding the circuitry of visual cortex and how it relates to cortical function...

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University of Utah President Taylor Randall has appointed John Moran Eye Center researcher Alessandra Angelucci to endowed chair. 1 April 2024 - University of Utah President Taylor Randall has appointed Moran Eye Center Professor Alessandra Angelucci...

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The John A. Moran Eye Center recently honored 12 of its University of Utah faculty scholars who hold endowed chairs and professorships and the generous donors who made the positions possible...

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The animal brain is so complex, it would take a supercomputer and vast amounts of data to create a detailed 3-D model of the billions of neurons that power it....

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Interactive software tool lets brain researchers explore large-scale, high-res imaging to better understand connections in the brain......

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RECENT PUBLICATIONS

2025

Villamarin-Ortiz A., Reiche C.F., Federer F., Clark A.M., Rolston J.D., Soto-Sánchez C., Fernandez E.*, Blair S.*, and Angelucci A.* (2025) Cortical Response to Acute Implantation of the Utah Optrode Array in Macaque Cortex. Advanced Healthcare Materials: in press. Preprint published in BioRxiv. doi: https://doi.org/10.1101/2025.01.13.632843. *Equal contribution

2024

Federer F., Balsor J., Ingold A., Babcock, D.P., Dimidschstein J., and AngelucciA. (2024) Laminar specificity and coverage of viral-mediated gene expression restricted to GABAergic interneurons and their parvalbumin subclass in marmoset primary visual cortex. eLife13:RP97673. Preprint published on March 11th 2024 in BioRxivdoi:https://doi.org/10.1101/2024.03.07.583998

2024

Clark A.M., Ingold A., Reiche C.F., Cundy D., Balsor J.L., Federer F., McAlinden N., Cheng Y., Rolston J.D., Rieth L., Dawson M. D., Mathieson K., Blair S. and Angelucci A. (2024) An Optrode Array for Spatiotemporally Precise Large-Scale Optogenetic Stimulation of Deep Cortical Layers in Non-human Primates. Communication Biology7:329. Preprint first published on Feb 10th 2022 in BioRxivdoi: https://doi.org/10.1101/2022.02.09.479779.

MAIN RESEARCH
INTERESTS

 

√ Connectivity and function of inhibitory neurons in visual cortex;
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√ Feedforward connections between visual cortical areas
  and feedforward processing;
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√ Feedback connections between visual cortical areas and
  feedback processing;
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√ Connectomics, and development of computational
  approaches for large scale connectomics;
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√ Contextual effects in visual cortex;
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√ Development of tools for large scale simultaneous
  optogenetics and recordings;
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√ Restoring Vision: visual cortical prosthesis

OUR RESEARCH IS SUPPORTED BY :

  • The National Science Foundation
  • The National Eye Institute: 2 R01 grants
  • The National Institute for Neurological Disorders and Stroke
  • University of Utah Mini-initiative Program Grant